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KMID : 0357920030370030214
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Korean Journal of Pathology
2003 Volume.37 No. 3 p.214 ~ p.217
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Sinonasal Undifferentiated Carcinoma - A Case Report -
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Kim Hwal-Woong
Ko Gyung-Hyuck
Kim Chul-Woo
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Abstract
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Sinonasal undifferentiated carcinoma (SNUC) is a rare, aggressive neoplasm arising in the nasal cavity and paranasal sinuses. We report a case of SNUC in an old woman. The tumor was located at the nasal cavity and ethmoid sinus, extending to the cranial cavity. The nasopharynx was free from the tumor. Microscopically, the tumor formed nests or sheets containing medium-sized cells with small amounts of eosinophilic cytoplasm. High mitotic rates and tumor necrosis were characteristic. There was no evidence of glandular or squamous differentiation. The tumor was focally weak positive for cytokeratin, but negative for vimentin, leukocyte common antigen, S-100 protein, chromogranin, synaptophysin and neuron specific enolase. Epstein Barr Virus EBER-1 was not detected by in situ hybridization. SNUC is a highly aggressive tumor and must be distinguished from less aggressive sinonasal neoplasms.
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KEYWORD
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Sinonasal Undifferentiated Carcinoma, Nasal Cavity, Paranasal Sinus, Keratin
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